SARS-CoV-2 NHP efficacy model is now available!

1 April 2021

Cynbiose has developed an efficacy model on the African Green Monkey (Chlorocebus aethiops) that shows SARS-CoV-2 replication in the oropharynx, nasal cavity and lungs as well as  mild symptoms (body temperature, neutrophilia, monocytosis, lung subacute or acute inflammation).

  • Infection is carried out using a realistic method : intranasal and intratracheal pulverization,
  • Different strains are available for the infectious challenge : Primary strain, various European D614G variants, UK variant,  South-African variant,
  • Viral load can be monitored by RT-qPCR and TCID50 from the upper or lower airways or from any organ collected post-necropsy,
  • The post infection monitoring period can range from 7 to 21 days depending on your scientific objectives.

The COVID-19 model is also available in the cynomolgus.

More information on our model is available on our dedicated page. Please contact us to test your vaccines, antibodies, immunotherapies , antiviral candidates and other type of treatments. We can also perform efficacy and tox studies with aerosoltherapies.

Share this!