SARS-CoV-2 NHP efficacy model is now available!

22 December 2020

Cynbiose has developed an efficacy model on the African Green Monkey (Chlorocebus aethiops) that shows SARS-CoV-2 replication in the oropharynx, nasal cavity and lungs as well as  mild symptoms (body temperature, neutrophilia, monocytosis, lung subacute or acute inflammation). Infection is performed using an realistic method, by intranasal and intratracheal pulverization of a French strain of the virus. Viral load can be monitored by RT-qPCR and TCID50 from the upper or lower airways or from any organ collected post-necropsy.

The post infection monitoring period can range from 7 to 21 days depending on your scientific objectives.

The model is also being developed in the cynomolgus and will be available by Q1 2021.

 

More information on our model is available on our dedicated page. Please contact us to test your vaccines, antibodies, immunotherapies , antiviral candidates and other type of treatments. We can also perform efficacy and tox studies with aerosoltherapies.

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