SARS-CoV-2 NHP efficacy model is now available!1 April 2021
Cynbiose has developed an efficacy model on the African Green Monkey (Chlorocebus aethiops) that shows SARS-CoV-2 replication in the oropharynx, nasal cavity and lungs as well as mild symptoms (body temperature, neutrophilia, monocytosis, lung subacute or acute inflammation).
- Infection is carried out using a realistic method : intranasal and intratracheal pulverization,
- Different strains are available for the infectious challenge : Primary strain, various European D614G variants, UK variant, South-African variant,
- Viral load can be monitored by RT-qPCR and TCID50 from the upper or lower airways or from any organ collected post-necropsy,
- The post infection monitoring period can range from 7 to 21 days depending on your scientific objectives.
The COVID-19 model is also available in the cynomolgus.
More information on our model is available on our dedicated page. Please contact us to test your vaccines, antibodies, immunotherapies , antiviral candidates and other type of treatments. We can also perform efficacy and tox studies with aerosoltherapies.