New scientific publication on our NHP model of cartilage defect

7 April 2021

Using an original non-human primate model of cartilage defect, Cynbiose enabled its partners to show the efficacy of a novel hydrogel for cartilage repair.

The preclinical in vivo assessment of the hydrogel engaftment relied on two main axes:

1) an animal model using facultative bipedal locomotion, with a knee structure similar to that of human (whereas most works rely on quadrupedals) and,

2) the use of state-of-the-art imaging methods of the knee joint.


Combining these two methods improved the translational value of the work made by Dr Dufour and his collaborators, with conclusions that could more easily be translated to a clinical setting.

Repair of full-thickness articular cartilage defects using IEIK13 self-assembling peptide hydrogel in a non-human primate model. Dufour A., Lafont M., Buffier M., Verset M., Cohendet A., Contamin H., Confais J., Rioult M., Perrier-Groult E., Mallein-Gerin F. Scientific Reports, 2021 Feb 25;11(1):4560.


Please contact us to discuss our innovative non-human primate efficacy model and your needs of preclinical assessment of candidates in osteoarthritis.


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