We are pleased to share our latest scientific publication related to our model of Experimental Autoimmune Encephalomyelitis (EAE) to assess drug candidates developed for multiple sclerosis.
This paper is the result of a fruitful collaboration between Dr Sergueira’s team (CEA, INSERM) and Cynbiose, showing how details that could be easily overlooked have a significant impact in the design of a relevant animal model of human pathology. In this paper, the authors and our Scientific Director Joachim Confais showed that a trace amount of impurity in the recombinant protein used in the induction of a primate model of EAE can impact the severity of the induced phenotype. The study indicates that by activating several TLRs, the trace amount of contaminant could be enough to induce a stronger immune response in the animals, thus increasing the severity of their symptoms.
🔸 This work thus improves our understanding of the fine mechanisms underlying the induction of the EAE in the monkey, a relevant model in the study of accute demyelinating diseases in adults and children.
🔸 🔸 For more information contact us at contact@cynbiose.com
Stimmer, L., Confais, J., Jong, A. et al. Recombinant myelin oligodendrocyte glycoprotein quality modifies evolution of experimental autoimmune encephalitis in macaques. Lab Invest (2021). https://doi.org/10.1038/s41374-021-00646-x
