This non-human primate (NHP) model induces chronic skin inflammation and plaques with lesions markedly similar to those observed in human patients.

This is a simple and fast in vivo model to evaluate the efficacy of your drug.

Model

  • Species: Cynomolgus macaque (Macaca fascicularis)
  • Topical application of  imiquimod (IMQ) cream triggering a dermal autoimmune response
  • Validation of the model : both clinical and histopathological validation

Type of test item

  • Immunotherapies
  • Immunomodulators

Efficacy readouts

  • Scoring of skin erythema, skin inflammation and other clinical signs lesions observed as in human
  • Clinical pathology
  • Immunomonitoring
  • Skin biopsies, tissue collection
  • Histopathology
  • Immunohistochemistry
  • On-demand and customized readouts