NHP model for Multiple Sclerosis

This model induces an auto-immune reaction of the animal against its own myelin sheet, thus reproducing the phenotype of several auto-immune demyelinating diseases (Serguera et al., 2019).

The Experimental Autoimmune Encephalomyelitis (EAE) NHP model has indeed been shown to mimic several aspects of the immune response, neuroinflammation and behavioral phenotype observed in the multiple sclerosis (Stimmer et al., 2018 & Stimmer et al, 2021).

Model

  • Species: Cynomolgus macaque (Macaca fascicularis)
  • Pharmacologically-induced autoimmune reaction

Type of test item

  • Neuroprotective or immunosuppressive therapeutic strategies in a neurological auto-immune disease
  • Novel imaging methods targeting the myelin sheet

Efficacy read-outs

  • MRI, PET-MRI Imaging
  • Daily neurological evaluation (proprietary scoring grid)
  • Clinical pathology
  • Immunomonitoring
  • On-demand and customized readouts

Scientific publications

  • MOG quality modifies evolution of EAE in macaques.
    Stimmer L, Confais J, Jong A, Verth J, Fovet  CM, Horellou P, Massonneau J, Perrin A,  Miotello G, Avazeri E, Hart B, Deiva K, Le Grand R, Armengaud J, Bajramovic J, Contamin H, and Serguera C.
    Laboratory Investigation, 2021, in press.

Reference compounds

  • Experimental tetramer

Scientific partners

  • CERMEP – Imagerie du Vivant, Lyon, France
  • CREATIS, CNRS UMR-5220, INSERM U1206, Université Lyon 1, France