Ischemic stroke

 

This minimally invasive model of cerebral ischemia-reperfusion is based on an endovascular transient occlusion and recanalization of the middle cerebral artery.

The model allows per-occlusion and immediate post-recanalization imaging, enables evaluation of the ischemic penumbra, target of neuroprotection intervention, in addition to acute and chronic neurofunctional assessments.

 

Model

  • Species: Cynomolgus macaque (Macaca fascicularis)
  • Innovative and translational mechanical induction
  • Transient model
  • Proprietary physiopathological model

Type of drugs

  • Neuroprotective drugs
  • Thrombolytic or anti-inflammatory drugs, …
  • Thrombectomy methods

 

 

 

 

Efficacy read-outs

  • PET/MRI imaging
  • Neurological evaluation with a proprietary observation scale (NHPNS)
    • Functional assessment
    • Fine motor function evaluation with a Hand Dexterity Task (HDT)
  • Cognitive function evaluation with a Delayed Response Task (DRT)
  • Clinical pathology
  • On-demand and customized read-outs

Scientific publications

  •  Wateau O*, Debatisse J*, Cho T.H , Costes N, Mérida I, Léon C, Langlois J.B, Taborik F, Verset M, Portier K, Aggour M, Troalen T, Villien M, Makris N, Tourvieille C, Le Bars D, Lancelot S, Confais J, Oudotte A. Nighoghossian N, Ovize M, Vivien D, Contamin H, Agin V, Canet-Soulas E, Eker O.F.
    A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs. Journal of Cerebral Blood Flow and Metabolism, May 19, 2020 (Online)
  • Debatisse J, Eker O.F., Wateau O, Cho T.H , Wiart M, Ramonet D, Costes N, Mérida I, Léon C, Dia M, Paillard M, Confais J, Rossetti F,  Langlois J.B, Troalen T, Iecker T, Le Bars D, Lancelot S, Bouchier B, Lukasziewicz AC, Oudotte A. Nighoghossian N, Ovize M, Contamin H, Lux F, Tillement O, Canet-Soulas E,
    PET-MRI nanoparticles imaging of bloodbrain barrier damage and modulation after stroke reperfusion. Brain Communications, Volume 2, Issue 2, 2020, fcaa193 (Available online)

Scientific partners

  • CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Lyon 1, France
  • PhInd Laboratory, INSERM UMR-S 1237, Institut Blood and Brain, GIP Cyceron, Caen, France
  • CREATIS, CNRS UMR-5220, INSERM U1206, Université Lyon 1, France
  • Hospices Civils of Lyon, France
  • CERMEP – Imagerie du Vivant, Lyon, France