Innovative NHP stroke model: a new scientific publication in JCBFM.

We are very proud to announce the publication of the our latest preclinical model of stroke.

Central to Dr Océane Wateau (Cynbiose) thesis was the establishment of a minimally invasive non-human primate model of cerebral ischemia (Macaca fascicularis) based on an endovascular transient occlusion and recanalization of the middle cerebral artery (MCA) and the implementation of neurological read-outs.

This innovative approach was also supported by PET-MRI imaging in addition to acute and chronic neuro-functional assessment.

The thesis was directed jointly by Cynbiose and Pr Denis Vivien’s team (UNICAEN, INSERM UMR-S 1237, “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen Normandie, GIP Cyceron, Caen, France).

This innovative and unique efficacy model was made possible thanks to the close collaboration with several renowned academic teams within the framework of the RHU Marvelous project.

A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs. 
Océane Wateau, Justine Debatisse,  Tae-Hee Cho,Nicolas Costes, Inés Mérida, Christelle Léon, Jean-Baptiste Langlois, Fabrice Taborik, Mickaël Verset, Karine Portier, Mohamed Aggour, Thomas Troalen, Marjorie Villien, Nikolaos Makris, Christian Tourvieille, Didier Le Bars, Sophie Lancelot, Joachim Confais, Adrien Oudotte, Norbert Nighoghossian, Michel Ovize, Denis Vivien, Hugues Contamin, Véronique Agin, Emmanuelle Canet-Soulas, Omer Faruk Eker.
Journal of Cerebral Blood Flow & Metabolism, May 2020.

Please contact us for more information on this model and for the preclinical evaluation of your candidates.