Cynbiose can assess the efficacy of your drug candidate in a translational non-human primate (NHP) model. This model is relevant to test innovative or repurposed drug candidates as well as aerosoltherapies.

Species

  • Cynomolgus macaque (Macaca fascicularis)
  • African green monkey (genus Chlorocebus)

Pathogen

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) / COVID-19 strains (Primary strain, various European D614G variants, UK variant,  South-African variant)
  • Infection method : intratracheal, intranasal pulverization

Type of test item

  • Vaccines, antibodies, immunotherapies, antiviral candidates, small molecules and combination of treatments
  • Aerosoltherapies

 

 

 

 

Read-outs

Clinical assessment

  • Body temperature monitoring (implanted logger)
  • Clinical pathology : biochemistry and complete blood count with differential in a BSL 2/3 setting thanks to state-of-the-art biological analyzers
  • Lung function measurement
  • Specific biomarkers


Infection monitoring

  • Sampling : Bronchoalveolar lavage, Nasal & nasopharyngeal swabs, blood sampling, feces
  • Virological analysis : local viremia, viral titer
  • Histopathology
  • Transcriptomics, Metagenomics
  • Immunomonitoring

Scientific publications

  • African Green Monkey model of SARS-CoV-2 infection shows mild lung pathology and viral replication in the airways.
    Confais J, Toussenot M, Julien T, Ployart S, Pizzorno A, Rosa-Calatrava M, Contamin H.
    Immunotherapies & Innovations for Infectious Diseases congress, 9-10th December, 2020.

Scientific partners

  • VirPath laboratory (Claude Bernard Lyon University, INSERM, CNRS, ENS Lyon) specializing in virology and human respiratory pathologies