This model induces ostearthritis (cartilage damage) and tissue responses that closely replicate the pathology as in humans.

It effectively mimics the early stages of human post-traumatic osteoarthritis (reduction of the cartilage thickness by 30%).



  • Species: Cynomolgus macaque (Macaca fascicularis)
  • Model based on a surgically-induced instability of the knee joint

Type of test item

  • Anti-inflammatory NCE
  • Anti-inflammatory biologics
  • Cartilage repair, chondrostimulant

Efficacy readouts

  • Daily clinical assessment : pain, locomotion, joint aperture angle
  • Clinical pathology
  • Sampling : blood, synovial lavage, …
  • Monitoring and automated quantification of the injuries by imaging modalities: µCT arthrography, MRI. Possibility to use advanced MRI sequences to investigate the cartilage structure.
  • Histopathology
  • Synovial, seral and urine specific biomarkers
  • On-demand and customized readouts

Validation of the model

  • Cartilage thinning observed by µCT arthrography
  • Monthly injection of Ostenyl Plus decreases the symptoms

Scientific publications

  • Eurostars innovative program, Cynbiose (Coordinator)

Scientific partners

  • Specializing preclinical CRO in tissue analysis (skin, bone and cartilage)
  • CREATIS, CNRS UMR-5220, INSERM U1206, Université Lyon 1