This unique minimally invasive acute myocardial ischemia/reperfusion model mimics physiologically acute effects of myocardial infarction (Acute coronary syndrome – ACS). This model displays coronary occlusion and reperfusion as in human patients, confirmed by advanced cardiac imaging and histopathological changes. The longitudinal analysis of chronic effects (left ventricular dysfunction) can be used for the pharmacological investigation of cardioprotective drugs.

 

Model

  • Species: Rhesus monkey (Macaca mulatta), Cynomolgus monkey (Macaca fascicularis)
  • Surgically induced model by endovascular catheterization with a trained interventional cardiologist.

 

Type of test item

  • Cardioprotective therapeutic strategies
  • Post-myocardial-infarction (MI) and anti-heart-failure drugs
  • Cell therapies
  • Immunomodulatory agents
  • Ultrasound contrast agent, radioactive tracers
  • Therapeutic interventions for protective properties

Efficacy read-outs

  • Clinical follow-up: clinical observation, body weight, food consumption
  • Noninvasive hemodynamic recordings
  • Clinical pathology
  • Immunomonitoring
  • Heart failure biomarkers
  • Monitoring of cardiac function: ultrasound imaging, scanner, MRI
  • Histopathology, IHC
  • On-demand and customized readouts

Scientific publications

  • Drut A. Establishment of a minimally-invasive post-ischemic model of chronic heart failure in cynomolgus monkeys (Macaca fascicularis).
    In: 12th European Primate Veterinarian (EPV) annual symposium, 27-28 Sept 2012
  • Contamin H. et al. A minimally-invasive closed chest myocardial occlusion-reperfusion model in rhesus monkeys (Macaca mulatta): monitoring by contrast-enhanced ultrasound imaging. Int J Cardiovasc Imaging. 2012 Mar; 28 (3): 531-542.

Scientific partners

  • CERMEP
  • CREATIS, CNRS UMR-5220, INSERM U1206, Université Lyon 1
  • CarMeN laboratory