Experimental Autoimmune Encephalomyelitis (EAE) model

NHP model for Multiple Sclerosis

This model induces an auto-immune reaction of the animal against its own myelin sheet, thus reproducing the phenotype of several auto-immune demyelinating diseases (Serguera et al., 2019).

The Experimental Autoimmune Encephalomyelitis (EAE) NHP model has indeed been shown to mimic several aspects of the immune response, neuroinflammation and behavioral phenotype observed in the multiple sclerosis (Stimmer et al., 2018 & Stimmer et al, 2021).

This model is not commercially available at the moment.

Model

Species: Cynomolgus macaque (Macaca fascicularis)
Pharmacologically-induced autoimmune reaction

Type of test item

Neuroprotective or immunosuppressive therapeutic strategies in a neurological auto-immune disease
Novel imaging methods targeting the myelin sheet

Efficacy read-outs

MRI, PET-MRI Imaging
Daily neurological evaluation (proprietary scoring grid)
Clinical pathology
Immunomonitoring
On-demand and customized readouts

Scientific publications

Recombinant myelin oligodendrocyte glycoprotein (MOG) quality modifies evolution of EAE in macaques.
Stimmer L, Confais J, Jong A, Verth J, Fovet CM, Horellou P, Massonneau J, Perrin A, Miotello G, Avazeri E, Hart B, Deiva K, Le Grand R, Armengaud J, Bajramovic J, Contamin H, and Serguera C.
Laboratory Investigation, August 2021.
https://doi.org/10.1038/s41374-021-00646-x