Immunopharmacology model
Delayed-type hypersensitivity (DTH) is a low invasive model based on the induction of local cellular immune responses.
This NHP model is reliable for the preclinical evaluation of cell-mediated immunity of biological drugs and non clinical immunotoxicity evaluation.
Model
- Species: Cynomolgus macaque (Macaca fascicularis)
- Model induced by KLH, Tetanus-based vaccine (TTx), BCG
Type of test item
- Immunosuppressive agents
- Immunomodulatory drugs
- Vaccines / adjuvants
Efficacy read-outs
- Clinical reactions at the injection sites (proprietary scoring grid)
- Clinical pathology
- Cutaneous reaction : morphological readouts, histopathology, immunohistochemistry
- Immunomonitoring
- On-demand and customized readouts
Scientific publications
- Développement préclinique des immunothérapies : apport des modèles PNH. Verset M, Mosca M, Panzuti P, Contamin H, Pin D. STAL. 2018, 46(2): 12-16.
- Preclinical development of immunotherapies for infectious diseases: relevance of the Non-Human Primate. Verset M, Contamin H. I4ID congress, 2017, 11-12 Dec. 2017, Lyon.
- Développement préclinique des immunothérapies : apport des modèles PNH. Verset M et al. 43ème colloque AFSTAL, 7-9 Juin 2017, Lyon.
