Diet-induced atherosclerosis

This diet-induced model mimics human atherosclerotic clinical conditions such as atherosclerotic lesions, increased risk of cardiovascular events and plaque formation.

Correlations between metabolic activity, inflammation, lymphocyte infiltration and vulnerable plaque markers were observed in the carotids and aortic arch, similar to the clinical setting.

This translational model is thus designed to test the efficacy of anti-atherosclerotic drugs and of biomarkers for risk stratification of the patients.

Model

Species: Cynomolgus macaque (Macaca fascicularis)
Diet-induced model (High fat, High Cholesterol)

Type of test item

Cardioprotective therapeutic strategies
Immunotherapies
Cell therapies
Oligonucleotide, ASO
Gene therapies, Viral vector-based therapies
Recombinant protein
Anti-inflammatory drugs

Efficacy read-outs

Clinical follow-up: clinical observation, body weight, food consumption
Noninvasive hemodynamic recordings
Clinicalpathology
Detailed lipidemia and cholesterolemia profile
Immunomonitoring
Biomarkers
Noninvasive imaging follow-up (ultrasound scan, MRI, PET scan) for precise detection and localisation of atheroma plaques
Histopathology, IHC
PET scan for atherosclerosis-related neuroinflammation

On-demand and customized readouts

Scientific publications

Di Cataldo V , Debatisse J, Piraquive J, Géloën A, Grandin C, Verset M, Taborik F, Labaronne E, Loizon E, Millon A, Mury P, Pialoux V, Serusclat A , Lamberton F, Ibarrola D, Lavenne F, Le Bars D, Troalen T, Confais J, Crola Da Silva C , Mechtouff L, Contamin H, A Fayad Z, Canet-Soulas E. Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model.
Brain Communications, 2021 Apr 1;3(2):fcab064. (Online)
Debatisse J., Makris N., Di Cataldo V., Portier K, Verset M., Wateau O., Langlois J.B., Lamberton F., Ibarolla D., Lavenne F., Le Bars D., Troalen T., Contamin H., Cho T.H., Canet-Soulas E. Supervised clustering analysis for quantification of neuroinflammation using [11C]PK11195 PET in young and old controls, and atherosclerotic non-human primates.
13th European Molecular Imaging Meeting (EMIM), 20-23 March 2018.

Di Cataldo et al. Markers of vulnerable plaques in Non-Human Primates under atherogenic diet. World Molecular Imaging Congress, 7-10 Sept 2016, New York.
Di Cataldo et al. MR and PET/CT Imaging using to stratify cardiovascular risks in Non-Human Primates under atherogenic diet. 11th International Conference on Cerebral Vascular Biology, 6-9 July 2015, Paris.