This diet-induced model mimics human atherosclerotic clinical conditions such as atherosclerotic lesions, increased risk of cardiovascular events and plaque formation.
Correlations between metabolic activity, inflammation, lymphocyte infiltration and vulnerable plaque markers were observed in the carotids and aortic arch, similar to the clinical setting.
This translational model is thus designed to test the efficacy of anti-atherosclerotic drugs and of biomarkers for risk stratification of the patients.
- Species: Cynomolgus macaque (Macaca fascicularis)
- Diet-induced model (High fat, High Cholesterol)
Type of test item
- Cardioprotective therapeutic strategies
- Cell therapies
- Oligonucleotide, ASO
- Gene therapies, Viral vector-based therapies
- Recombinant protein
- Anti-inflammatory drugs
- Clinical follow-up: clinical observation, body weight, food consumption
- Noninvasive hemodynamic recordings
- Detailed lipidemia and cholesterolemia profile
- Noninvasive imaging follow-up (ultrasound scan, MRI, PET scan) for precise detection and localisation of atheroma plaques
- Histopathology, IHC
- PET scan for atherosclerosis-related neuroinflammation
- On-demand and customized readouts
- Di Cataldo V , Debatisse J, Piraquive J, Géloën A, Grandin C, Verset M, Taborik F, Labaronne E, Loizon E, Millon A, Mury P, Pialoux V, Serusclat A , Lamberton F, Ibarrola D, Lavenne F, Le Bars D, Troalen T, Confais J, Crola Da Silva C , Mechtouff L, Contamin H, A Fayad Z, Canet-Soulas E. Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model.
Brain Communications, 2021 Apr 1;3(2):fcab064. (Online)
- Debatisse J., Makris N., Di Cataldo V., Portier K, Verset M., Wateau O., Langlois J.B., Lamberton F., Ibarolla D., Lavenne F., Le Bars D., Troalen T., Contamin H., Cho T.H., Canet-Soulas E. Supervised clustering analysis for quantification of neuroinflammation using [11C]PK11195 PET in young and old controls, and atherosclerotic non-human primates.
13th European Molecular Imaging Meeting (EMIM), 20-23 March 2018.
- Di Cataldo et al. Markers of vulnerable plaques in Non-Human Primates under atherogenic diet. World Molecular Imaging Congress, 7-10 Sept 2016, New York.
- Di Cataldo et al. MR and PET/CT Imaging using to stratify cardiovascular risks in Non-Human Primates under atherogenic diet. 11th International Conference on Cerebral Vascular Biology, 6-9 July 2015, Paris.
- CERMEP – Imagerie du Vivant, Lyon, France
- CREATIS, CNRS UMR-5220, INSERM U1206, Université Lyon 1, France
- CarMeN laboratory