A model of focal cartilage defect to assess the efficacy of biomaterials (hydrogels) or cell-based reconstructive therapies.



  • Species: Cynomolgus macaque (Macaca fascicularis)
  • Surgically induced model: focal defect of the knee’s cartilage


Type of test item

  • Biomaterials (e.g. hydrogel)
  • Cell type such as articular chondrocytes, adipose-derived stem cells, human Mesenchymal Stem Cells (MSCs), …
  • Cell printing technologies

Efficacy readouts

  • Non-invasive imaging follow-up: µCT arthrography, MRI
  • Daily clinical assessment: pain, locomotion
  • Clinical pathology
  • Sampling : blood, synovial fluids, …
  • Histopathology, IHC
  • Biomarkers
  • On-demand and customized readouts

Validation of the model

  • Consistent results between histology and µCT arthrography
  • Cell-loaded (autograft) and cell-free hydrogel

Scientific publications

  • Dufour A., Lafont M., Buffier M., Verset M., Cohendet A., Contamin H., Confais J., Rioult M., Perrier-Groult E., Mallein-Gerin F. Repair of full-thickness articular cartilage defects using IEIK13 self-assembling peptide hydrogel in a non-human primate model.
    Scientific Reports, 2021 Feb 25;11(1):4 560. Publication
  • Dufour A., Verset M., Cohendet A., Buffier M., Rioult M., Contamin H., Groult E., Mallein-Gérin F. Use of autologous chondrocyte-seeded hydrogel to treat focal cartilage defect in non-human primate.
    International Cartilage Repair Society 2018 14th World Congress, 9-12 April 2018, Macao (China).  Poster
  • Dufour A., Verset M., Cohendet A., Buffier M., Rioult M., Contamin H., Perrier-Groult E., Mallein-Gerin F. Repair of Osteochondral Defect in a Non-Human Primate Model Using Autologous Chondrocyte-seeded Hydrogels.
    European Cells & Materials 13rd Conference, 25-28 June 2018, Davos.

Scientific partners

  • Specializing preclinical CRO in tissue analysis (skin, bone and cartilage)
  • IBCP (UMS3760)