A model of focal cartilage defect to assess the efficacy of biomaterials (hydrogels) or cell-based reconstructive therapies.
Model
- Species: Cynomolgus macaque (Macaca fascicularis)
- Surgically induced model: focal defect of the knee’s cartilage
Type of test item
- Biomaterials (e.g. hydrogel)
- Cell type such as articular chondrocytes, adipose-derived stem cells, human Mesenchymal Stem Cells (MSCs), …
- Cell printing technologies
Efficacy readouts
- Non-invasive imaging follow-up: µCT arthrography, MRI
- Daily clinical assessment: pain, locomotion
- Clinical pathology
- Sampling : blood, synovial fluids, …
- Histopathology, IHC
- Biomarkers
- On-demand and customized readouts
Validation of the model
- Consistent results between histology and µCT arthrography
- Cell-loaded (autograft) and cell-free hydrogel
Scientific publications
- Dufour A., Lafont M., Buffier M., Verset M., Cohendet A., Contamin H., Confais J., Rioult M., Perrier-Groult E., Mallein-Gerin F. Repair of full-thickness articular cartilage defects using IEIK13 self-assembling peptide hydrogel in a non-human primate model.
Scientific Reports, 2021 Feb 25;11(1):4 560. Publication - Dufour A., Verset M., Cohendet A., Buffier M., Rioult M., Contamin H., Groult E., Mallein-Gérin F. Use of autologous chondrocyte-seeded hydrogel to treat focal cartilage defect in non-human primate.
International Cartilage Repair Society 2018 14th World Congress, 9-12 April 2018, Macao (China). Poster - Dufour A., Verset M., Cohendet A., Buffier M., Rioult M., Contamin H., Perrier-Groult E., Mallein-Gerin F. Repair of Osteochondral Defect in a Non-Human Primate Model Using Autologous Chondrocyte-seeded Hydrogels.
European Cells & Materials 13rd Conference, 25-28 June 2018, Davos.
Scientific partners
- Specializing preclinical CRO in tissue analysis (skin, bone and cartilage)
- VOXCAN
- CERMEP
- IBCP (UMS3760)
